glutathione peroxidase

glutathione peroxidase
A detoxifying enzyme that eliminates hydrogen peroxide and organic peroxides. Glutathione is an essential cofactor for the enzyme and its reaction involves the oxidation of glutathione (GSH) to glutathione disulphide (GSSG). The GSSG is then reduced to GSH by glutathione reductase. Glutathione peroxidase, (GPX), has a selenocysteine residue in its active site. Three forms of the enzyme exist: cytoplasmic GPX, plasma GPX and phospholipid hydroperoxide GPX.

Dictionary of molecular biology. 2004.

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  • Glutathione peroxidase — protein Name = glutathione peroxidase 1 caption = width = 240 px HGNCid = 4553 Symbol = GPX1 AltSymbols = EntrezGene = 2876 OMIM = 138320 RefSeq = NM 000581 UniProt = P07203 PDB = ECnumber = Chromosome = 3 Arm = p Band = 21.3… …   Wikipedia

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  • glutathione peroxidase — noun an enzyme in the body that is a powerful scavenger of free radicals • Hypernyms: ↑peroxidase, ↑antioxidant …   Useful english dictionary

  • Phospholipid-hydroperoxide glutathione peroxidase — In enzymology, a phospholipid hydroperoxide glutathione peroxidase (EC number| is an enzyme that catalyzes the chemical reaction:2 glutathione + a lipid hydroperoxide ightleftharpoons glutathione disulfide + lipid + 2 H2OThus, the two… …   Wikipedia

  • Glutathione — Glutathione[1] …   Wikipedia

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  • glutathione — The tripeptide g glutamylcysteinylglycine. It contains an unusual peptide linkage between the g carboxyl group of the glutamate side chain and the amine group of cysteine. The concentration of glutathione in animal cells is around 5mM and its… …   Dictionary of molecular biology

  • glutathione — A tripeptide of glycine, l cysteine, and l glutamate, with l glutamate having an isopeptide bond with the amino moiety of l cysteine. G. has a wide variety of roles in a cell; it is the most prevalent non protein thiol. G. disulfide (GSSG)… …   Medical dictionary

  • Phospholipid-Hydroxyperoxid-Glutathion-Peroxidase — Vorhandene Strukturdaten …   Deutsch Wikipedia

  • Cytochrome c peroxidase — Cytochrome c peroxidase, or CCP (PDB 2CYP, EC is a water soluble heme containing enzyme of the peroxidase family that takes reducing equivalents from cytochrome c and reduces hydrogen peroxide to water: CCP + H2O2 + 2 ferrocytochrome c… …   Wikipedia

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